REDUCING GLOBAL PERIOPERATIVE RISK
This resource center is jointly hosted by The American Journal of Medicine,
The American Journal of Cardiology, and the Canadian Journal of Cardiology.
Key Highlights
- The authors conducted a systematic review and individual patient meta-analysis to examine the prognostic value of natriuretic peptides (NP) in patients undergoing non-cardiac surgery.
- The study main objectives were to determine if adding preoperative NP measurement could enhance clinician’s ability to predict a composite of death and non-fatal myocardial infarction at 30 days and ≥180 days after non-cardiac surgery.
- Individual patient data were obtained from 18 eligible studies for a total of 2179 patients; 10 studies measured NT-proBNP and 8 studies measured BNP.
- The authors performed analysis to determine the NP threshold associated with the lowest p value for the composite outcome of death and non-fatal myocardial infarction.
- A net reclassification approach was used to determine if NP provided additional prognostic information in addition to a clinical model (ie, Revised Cardiac Risk Index) based on risk categories of <5%, 5-10%, >10-15%, and >15%.
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