REDUCING GLOBAL PERIOPERATIVE RISK
This resource center is jointly hosted by The American Journal of Medicine,
The American Journal of Cardiology, and the Canadian Journal of Cardiology.
KEY HIGHLIGHTS
- Trials of beta blockers in patients undergoing non-cardiac surgery have historically reported conflicting results. POISE was a randomized controlled trial, involving 190 hospitals across 23 countries, designed to investigate the effects of perioperative beta blockers.
- The study randomly assigned 8351 patients with, or at risk of, atherosclerotic disease who were undergoing non-cardiac surgery to receive extended-release metoprolol succinate (n=4174) or placebo (n=4177), by a computerized randomization phone service; participants were >45 years old, undergoing non-cardiac surgery, and at risk of cardiovascular complication.
- Study treatment was started 2-4 h before surgery and continued for 30 days.
- Patients, healthcare providers, data collectors, and outcome adjudicators were masked to treatment allocation. The primary endpoint was a composite of cardiovascular death, non-fatal myocardial infarction, and non-fatal cardiac arrest.
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