REDUCING GLOBAL PERIOPERATIVE RISK
This resource center is jointly hosted by The American Journal of Medicine,
The American Journal of Cardiology, and the Canadian Journal of Cardiology.
KEY FINDINGS
- Clonidine had no effect on death or myocardial infarction. Clonidine was associated with an increased risk of non-fatal cardiac arrest and hypotension.
- ASA had no effect on death or myocardial infarction, but increased the risk of major and life-threatening bleeding.
- POISE 2 demonstrated that clinicians can improve outcomes by holding ASA during the perioperative period.
- Perioperative hypotension and major/life threatening bleeding were independent predictors of perioperative myocardial infarction.
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