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REDUCING GLOBAL PERIOPERATIVE RISK


This resource center is jointly hosted by The American Journal of Medicine,
The American Journal of Cardiology, and the Canadian Journal of Cardiology.

Risk Prediction

key Findings

  • The overall incidence of the composite of death and non-fatal myocardial infarction at 30 days was 10.8% (235 events).
  • NP threshold values associated with lowest p value for death and myocardial infarction for BNP was 92 ng/L and for NT-proBNP was 300 ng/L.
  • The incidence of death and non-fatal myocardial infarction at 30 days was 21.8% in patients who had a positive preoperative NT-proBNP (≥300 ng/L ) or BNP (≥92 ng/L), compared to 4.9% in patients who had a negative preoperative NT-proBNP (<300 ng/L) or BNP (<92 ng/L).

Key Highlights

  • The authors conducted a systematic review and individual patient meta-analysis to examine the prognostic value of natriuretic peptides (NP) in patients undergoing non-cardiac surgery.
  • The study main objectives were to determine if adding preoperative NP measurement could enhance clinician’s ability to predict a composite of death and non-fatal myocardial infarction at 30 days and ≥180 days after non-cardiac surgery.

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Funding for this site was received from the PHRI via support from the Canadian Institutes of Health Research’s Strategy for
Patient Oriented Research, through the Ontario SPOR Support Unit, as well as the Ontario Ministry of Health and Long-Term Care.